Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice
نویسندگان
چکیده
منابع مشابه
Vibrissa-signaled eyeblink conditioning induces somatosensory cortical plasticity.
Whisker deflection conditioned stimuli (CS) were demonstrated to activate physiologically and anatomically defined barrels in the contralateral somatosensory cortex and to support trace-eyeblink conditioned responses when paired with corneal airpuff unconditioned stimuli in rabbits. Analysis of cytochrome-oxidase-stained somatosensory whisker-associated cortical barrels revealed a row-specific ...
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Eyeblink conditioning in restrained rabbits has served as an excellent model of cerebellar-dependent motor learning for many decades. In mice, the role of the cerebellum in eyeblink conditioning is less clear and remains controversial, partly because learning appears to engage fear-related circuits and lesions of the cerebellum do not abolish the learned behavior completely. Furthermore, experi...
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We have previously shown that intracerebellar infusion of the neuropeptide secretin enhances the acquisition phase of eyeblink conditioning (EBC). Here, we sought to test whether endogenous secretin also regulates EBC and to test whether the effect of exogenous and endogenous secretin is specific to acquisition. In Experiment 1, rats received intracerebellar infusions of the secretin receptor a...
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A Novel Two-alternative Forced Choice Paradigm for Bilateral 3 Vibrotactile Whisker Frequency Discrimination in Head-Fixed Mice 4 and Rats 5 Johannes M. Mayrhofer, Vida Skreb, Wolfger von der Behrens, Simon Musall, Bruno Weber and 6 Florent Haiss* 7 8 Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland 9 10 Running title: bilateral frequency discrimination in hea...
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The cerebellum is considered a brain structure in which memories for learned motor responses (e.g., conditioned eyeblink responses) are stored. Within the cerebellum, however, the relative importance of the cortex and the deep nuclei in motor learning/memory is not entirely clear. In this study, we show that the cerebellar cortex exerts both basal and stimulus-activated inhibition to the deep n...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2016
ISSN: 1940-087X
DOI: 10.3791/53310